Deletion or Inhibition of Astrocytic Transglutaminase 2 Promotes Functional Recovery after Spinal Cord Injury

Deletion or Inhibition of Astrocytic Transglutaminase 2 Promotes Functional Recovery after Spinal Cord Injury

Following CNS injury, astrocytes become “reactive” and exhibit pro-regenerative or harmful properties. However, the molecular mechanisms that cause astrocytes to adopt either phenotype are not well understood. Transglutaminase 2 (TG2) plays a key role in regulating the response of astrocytes to insu...

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Bibliographic Details
Main Authors: Anissa Elahi, Jacen Emerson, Jacob Rudlong, Jeffrey W. Keillor, Garrick Salois, Adam Visca, Peter Girardi, Gail V.W. Johnson, Christoph Pröschel
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cells
Subjects:
transglutaminase 2
spinal cord injury
astrocytes
regeneration
GFAP
SOX9
Online Access:https://www.mdpi.com/2073-4409/10/11/2942

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https://www.mdpi.com/2073-4409/10/11/2942

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