MCL-1 is a master regulator of cancer dependency on fatty acid oxidation

MCL-1 is a master regulator of cancer dependency on fatty acid oxidation

Summary: MCL-1 is an anti-apoptotic BCL-2 family protein essential for survival of diverse cell types and is a major driver of cancer and chemoresistance. The mechanistic basis for the oncogenic supremacy of MCL-1 among its anti-apoptotic homologs is unclear and implicates physiologic roles of MCL-1...

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Bibliographic Details
Main Authors: Michelle S. Prew, Utsarga Adhikary, Dong Wook Choi, Erika P. Portero, Joao A. Paulo, Pruthvi Gowda, Amit Budhraja, Joseph T. Opferman, Steven P. Gygi, Nika N. Danial, Loren D. Walensky
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Cell Reports
Subjects:
CP: Cancer
CP: Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124722012864

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http://www.sciencedirect.com/science/article/pii/S2211124722012864

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