Glycogen synthase kinase-3β inhibition enhances myelination in preterm newborns with intraventricular hemorrhage, but not recombinant Wnt3A

Glycogen synthase kinase-3β inhibition enhances myelination in preterm newborns with intraventricular hemorrhage, but not recombinant Wnt3A

Intraventricular hemorrhage (IVH) in preterm infants results in reduced proliferation and maturation of oligodendrocyte progenitor cells (OPCs), and survivors exhibit reduced myelination and neurological deficits. Wnt signaling regulates OPC maturation and myelination in a context dependent manner....

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Bibliographic Details
Main Authors: Preeti Dohare, Bokun Cheng, Ehsan Ahmed, Vivek Yadala, Pranav Singla, Sunisha Thomas, Robert Kayton, Zoltan Ungvari, Praveen Ballabh
Format: Article
Language:English
Published: Elsevier 2018-10-01
Series:Neurobiology of Disease
Subjects:
Wnt3A
GSK-3β
Oligodendrocyte precursor cell
Myelination
Inflammation
Notch
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118301943

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http://www.sciencedirect.com/science/article/pii/S0969996118301943

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