Dopamine D2–Receptor Antagonists Ameliorate Indomethacin-Induced Small Intestinal Ulceration in Mice by Activating α7 Nicotinic Acetylcholine Receptors

Dopamine D2–Receptor Antagonists Ameliorate Indomethacin-Induced Small Intestinal Ulceration in Mice by Activating α7 Nicotinic Acetylcholine Receptors

Abstract.: We have reported that nicotine and the specific α7AChR agonist ameliorate indomethacin-induced intestinal lesions in mice by activating α7 nicotinic acetylcholine receptors (α7nAChR). Dopamine D2–receptor antagonists, such as domperidone and metoclopramide, enhance the release of ACh from...

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Bibliographic Details
Main Authors: Masashi Yasuda, Ryoji Kawahara, Hiroshi Hashimura, Naoki Yamanaka, Maho Iimori, Kikuko Amagase, Shinichi Kato, Koji Takeuchi
Format: Article
Language:English
Published: Elsevier 2011-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319306887

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http://www.sciencedirect.com/science/article/pii/S1347861319306887

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