Age-dependent decrease in glutamine synthetase expression in the hippocampal astroglia of the triple transgenic Alzheimer's disease mouse model: mechanism for deficient glutamatergic transmission?

Age-dependent decrease in glutamine synthetase expression in the hippocampal astroglia of the triple transgenic Alzheimer's disease mouse model: mechanism for deficient glutamatergic transmission?

<p>Abstract</p> <p>Astrocytes are fundamental for brain homeostasis and the progression and outcome of many neuropathologies including Alzheimer's disease (AD). In the triple transgenic mouse model of AD (3xTg-AD) generalised hippocampal astroglia atrophy precedes a restricted...

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Bibliographic Details
Main Authors: Verkhratsky Alexei, Noristani Harun N, Olabarria Markel, Rodríguez José J
Format: Article
Language:English
Published: BMC 2011-07-01
Series:Molecular Neurodegeneration
Subjects:
Astroglia
Alzheimer's disease
glutamine synthetase
GFAP
amyloid beta
excitotoxicity
hippocampus
plasticity
Online Access:http://www.molecularneurodegeneration.com/content/6/1/55

Internet

http://www.molecularneurodegeneration.com/content/6/1/55

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