A conformational switch high-throughput screening assay and allosteric inhibition of the flavivirus NS2B-NS3 protease.

A conformational switch high-throughput screening assay and allosteric inhibition of the flavivirus NS2B-NS3 protease.

The flavivirus genome encodes a single polyprotein precursor requiring multiple cleavages by host and viral proteases in order to produce the individual proteins that constitute an infectious virion. Previous studies have revealed that the NS2B cofactor of the viral NS2B-NS3 heterocomplex protease d...

Full description

Bibliographic Details
Main Authors: Matthew Brecher, Zhong Li, Binbin Liu, Jing Zhang, Cheri A Koetzner, Adham Alifarag, Susan A Jones, Qishan Lin, Laura D Kramer, Hongmin Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-05-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC5462475?pdf=render

Internet

http://europepmc.org/articles/PMC5462475?pdf=render

Similar Items