The Cdkn2a gene product p19 alternative reading frame (p19ARF) is a critical regulator of IFNβ-mediated Lyme arthritis.

The Cdkn2a gene product p19 alternative reading frame (p19ARF) is a critical regulator of IFNβ-mediated Lyme arthritis.

Type I interferon (IFN) has been identified in patients with Lyme disease, and its abundant expression in joint tissues of C3H mice precedes development of Lyme arthritis. Forward genetics using C3H mice with severe Lyme arthritis and C57BL/6 (B6) mice with mild Lyme arthritis identified the Borreli...

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Bibliographic Details
Main Authors: Jinze Li, Ying Ma, Jackie K Paquette, Amanda C Richards, Matthew A Mulvey, James F Zachary, Cory Teuscher, Janis J Weis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-03-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1010365

Internet

https://doi.org/10.1371/journal.ppat.1010365

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