Non-Muscle Myosin II Is Essential for the Negative Regulation of B-Cell Receptor Signaling and B-Cell Activation

Non-Muscle Myosin II Is Essential for the Negative Regulation of B-Cell Receptor Signaling and B-Cell Activation

Antigen (Ag)-triggered B-cell receptor (BCR) signaling initiates antibody responses. However, prolonged or uncontrolled BCR signaling is associated with the development of self-reactive B-cells and autoimmune diseases. We previously showed that actin-mediated B-cell contraction on Ag-presenting surf...

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Bibliographic Details
Main Authors: Margaret K. Seeley-Fallen, Michelle Lazzaro, Chaohong Liu, Quan-Zhen Li, Arpita Upadhyaya, Wenxia Song
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Immunology
Subjects:
B lymphocytes
B-cell receptor
actin cytoskeleton
non-muscle myosin II
signal transduction
antibody response
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.842605/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.842605/full

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