Targeting BPTF Sensitizes Pancreatic Ductal Adenocarcinoma to Chemotherapy by Repressing ABC-Transporters and Impairing Multidrug Resistance (MDR)

Targeting BPTF Sensitizes Pancreatic Ductal Adenocarcinoma to Chemotherapy by Repressing ABC-Transporters and Impairing Multidrug Resistance (MDR)

Pancreatic ductal adenocarcinoma (PDA) is characterized by an extremely poor prognosis due to its late diagnosis and strong chemoresistance to the current treatments. Therefore, finding new therapeutic targets is an urgent need nowadays. In this study, we report the role of the chromatin remodeler B...

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Bibliographic Details
Main Authors: Raúl Muñoz Velasco, Paula Jiménez Sánchez, Ana García García, Raquel Blanco Martinez-Illescas, Ángela Pastor Senovilla, Marian Lozano Yagüe, Alfonsina Trento, Rosa María García-Martin, Diego Navarro, Bruno Sainz, José Luis Rodríguez Peralto, Víctor Javier Sánchez-Arévalo Lobo
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cancers
Subjects:
BPTF
pancreatic cancer
ABC-transporters
multidrug resistance
gemcitabine
Online Access:https://www.mdpi.com/2072-6694/14/6/1518

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https://www.mdpi.com/2072-6694/14/6/1518

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