Myogenic tissue nanotransfection improves muscle torque recovery following volumetric muscle loss

Abstract This work rests on our non-viral tissue nanotransfection (TNT) platform to deliver MyoD (TNTMyoD) to injured tissue in vivo. TNTMyoD was performed on skin and successfully induced expression of myogenic factors. TNTMyoD was then used as a therapy 7 days following volumetric muscle loss (VML...

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Bibliographic Details
Main Authors: Andrew Clark, Subhadip Ghatak, Poornachander Reddy Guda, Mohamed S. El Masry, Yi Xuan, Amy Y. Sato, Teresita Bellido, Chandan K. Sen
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:npj Regenerative Medicine
Online Access:https://doi.org/10.1038/s41536-022-00259-y