Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors

Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors

“Although aberrant promoter DNA hypermethylation is a hallmark of cancer, it is not clear whether it is sufficient to drive transformation. Here, the authors use CRISPR-dCas9 to perform hit-and-run epigenetic editing, which prevents senescence entry in primary breast cells from healthy donors.”

Bibliographic Details
Main Authors: Emily A. Saunderson, Peter Stepper, Jennifer J. Gomm, Lily Hoa, Adrienne Morgan, Michael D. Allen, J. Louise Jones, John G. Gribben, Tomasz P. Jurkowski, Gabriella Ficz
Format: Article
Language:English
Published: Nature Portfolio 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01078-2

Internet

https://doi.org/10.1038/s41467-017-01078-2

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