Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors
“Although aberrant promoter DNA hypermethylation is a hallmark of cancer, it is not clear whether it is sufficient to drive transformation. Here, the authors use CRISPR-dCas9 to perform hit-and-run epigenetic editing, which prevents senescence entry in primary breast cells from healthy donors.”
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-01078-2 |
| _version_ | 1819129473482620928 |
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| author | Emily A. Saunderson Peter Stepper Jennifer J. Gomm Lily Hoa Adrienne Morgan Michael D. Allen J. Louise Jones John G. Gribben Tomasz P. Jurkowski Gabriella Ficz |
| author_facet | Emily A. Saunderson Peter Stepper Jennifer J. Gomm Lily Hoa Adrienne Morgan Michael D. Allen J. Louise Jones John G. Gribben Tomasz P. Jurkowski Gabriella Ficz |
| author_sort | Emily A. Saunderson |
| collection | DOAJ |
| description | “Although aberrant promoter DNA hypermethylation is a hallmark of cancer, it is not clear whether it is sufficient to drive transformation. Here, the authors use CRISPR-dCas9 to perform hit-and-run epigenetic editing, which prevents senescence entry in primary breast cells from healthy donors.” |
| first_indexed | 2024-12-22T08:44:17Z |
| format | Article |
| id | doaj.art-cc5d45d93ae34cfa90c771738264e95a |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-22T08:44:17Z |
| publishDate | 2017-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-cc5d45d93ae34cfa90c771738264e95a2022-12-21T18:32:09ZengNature PortfolioNature Communications2041-17232017-11-018111510.1038/s41467-017-01078-2Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donorsEmily A. Saunderson0Peter Stepper1Jennifer J. Gomm2Lily Hoa3Adrienne Morgan4Michael D. Allen5J. Louise Jones6John G. Gribben7Tomasz P. Jurkowski8Gabriella Ficz9Barts Cancer Institute, John Vane Science Centre, Charterhouse Square, Queen Mary University of LondonInstitute for Biochemistry and Technical Biochemistry, Department of Biochemistry, Faculty of Chemistry, University of StuttgartBarts Cancer Institute, John Vane Science Centre, Charterhouse Square, Queen Mary University of LondonBarts Cancer Institute, John Vane Science Centre, Charterhouse Square, Queen Mary University of LondonBarts Cancer Institute, John Vane Science Centre, Charterhouse Square, Queen Mary University of LondonBarts Cancer Institute, John Vane Science Centre, Charterhouse Square, Queen Mary University of LondonBarts Cancer Institute, John Vane Science Centre, Charterhouse Square, Queen Mary University of LondonBarts Cancer Institute, John Vane Science Centre, Charterhouse Square, Queen Mary University of LondonInstitute for Biochemistry and Technical Biochemistry, Department of Biochemistry, Faculty of Chemistry, University of StuttgartBarts Cancer Institute, John Vane Science Centre, Charterhouse Square, Queen Mary University of London“Although aberrant promoter DNA hypermethylation is a hallmark of cancer, it is not clear whether it is sufficient to drive transformation. Here, the authors use CRISPR-dCas9 to perform hit-and-run epigenetic editing, which prevents senescence entry in primary breast cells from healthy donors.”https://doi.org/10.1038/s41467-017-01078-2 |
| spellingShingle | Emily A. Saunderson Peter Stepper Jennifer J. Gomm Lily Hoa Adrienne Morgan Michael D. Allen J. Louise Jones John G. Gribben Tomasz P. Jurkowski Gabriella Ficz Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors Nature Communications |
| title | Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors |
| title_full | Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors |
| title_fullStr | Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors |
| title_full_unstemmed | Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors |
| title_short | Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors |
| title_sort | hit and run epigenetic editing prevents senescence entry in primary breast cells from healthy donors |
| url | https://doi.org/10.1038/s41467-017-01078-2 |
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