Quantifying the Predictive Accuracy of a Polygenic Risk Score for Predicting Incident Cancer Cases : Application to the CARTaGENE Cohort

Quantifying the Predictive Accuracy of a Polygenic Risk Score for Predicting Incident Cancer Cases : Application to the CARTaGENE Cohort

With the increasing use of polygenic risk scores (PRS) there is a need for adapted methods to evaluate the predictivity of these tools. In this work, we propose a new pseudo-R2 criterion to evaluate PRS predictive accuracy for time-to-event data. This new criterion is related to the score statistic...

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Bibliographic Details
Main Authors: Julianne Duhazé, Rodolphe Jantzen, Yves Payette, Thibault De Malliard, Catherine Labbé, Nolwenn Noisel, Philippe Broët
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Genetics
Subjects:
pseudo-R2
polygenic risk score
survival models
survival mixture model
breast cancer
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2020.00408/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2020.00408/full

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