Design, Synthesis, and Antiproliferative Activity of Selective Histone Deacetylases 6 Inhibitors Containing a Tetrahydropyridopyrimidine Scaffold

Design, Synthesis, and Antiproliferative Activity of Selective Histone Deacetylases 6 Inhibitors Containing a Tetrahydropyridopyrimidine Scaffold

The development of selective histone deacetylase 6 inhibitors (sHDAC6is) is being recognized as a therapeutic approach for cancers. In this paper, we designed a series of novel tetrahydropyridopyrimidine derivatives as sHDAC6 inhibitors. The most potent compound, 8-(2, 4-bis(3-methoxyphenyl)-5, 8-di...

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Bibliographic Details
Main Authors: Bin Wang, Youcai Liu, Lejing Zhang, Yajuan Wang, Zhaoxi Li, Xin Chen
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Molecules
Subjects:
HDAC6 inhibitor
tetrahydropyridopyrimidine
antitumor
synthesis
selectivity
Online Access:https://www.mdpi.com/1420-3049/28/21/7323

Internet

https://www.mdpi.com/1420-3049/28/21/7323

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