High-Throughput Genetic Screen for Synaptogenic Factors: Identification of LRP6 as Critical for Excitatory Synapse Development

High-Throughput Genetic Screen for Synaptogenic Factors: Identification of LRP6 as Critical for Excitatory Synapse Development

Genetic screens in invertebrates have discovered many synaptogenic genes and pathways. However, similar genetic studies have not been possible in mammals. We have optimized an automated high-throughput platform that employs automated liquid handling and imaging of primary mammalian neurons. Using th...

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Bibliographic Details
Main Authors: Kamal Sharma, Se-Young Choi, Yong Zhang, Thomas J.F. Nieland, Shunyou Long, Min Li, Richard L. Huganir
Format: Article
Language:English
Published: Elsevier 2013-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713006578

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http://www.sciencedirect.com/science/article/pii/S2211124713006578

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