Synergistic Suppression of NF1 Malignant Peripheral Nerve Sheath Tumor Cell Growth in Culture and Orthotopic Xenografts by Combinational Treatment with Statin and Prodrug Farnesyltransferase Inhibitor PAMAM G4 Dendrimers

Synergistic Suppression of NF1 Malignant Peripheral Nerve Sheath Tumor Cell Growth in Culture and Orthotopic Xenografts by Combinational Treatment with Statin and Prodrug Farnesyltransferase Inhibitor PAMAM G4 Dendrimers

Neurofibromatosis type 1 (NF1) is a disorder in which RAS is constitutively activated due to the loss of the Ras-GTPase-activating activity of neurofibromin. RAS must be prenylated (i.e., farnesylated or geranylgeranylated) to traffic and function properly. Previous studies showed that the anti-grow...

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Bibliographic Details
Main Authors: John J. Reiners, Patricia A. Mathieu, Mary Gargano, Irene George, Yimin Shen, John F. Callaghan, Richard F. Borch, Raymond R. Mattingly
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Cancers
Subjects:
MPNST
RAS prenylation
farnesyltransferase inhibitor
sciatic nerve
Online Access:https://www.mdpi.com/2072-6694/16/1/89

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https://www.mdpi.com/2072-6694/16/1/89

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