Preparation and pharmacological characterization of the enantiomers of the anticancer agent R/S-N-3-cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea: Identification of the R-enantiomer as the active eutomer

Preparation and pharmacological characterization of the enantiomers of the anticancer agent R/S-N-3-cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea: Identification of the R-enantiomer as the active eutomer

R/S-N-3-cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea (BPDZ 711, 4) initially designed as a KATP channel opener, was found to exhibit diverse biological activities. The compound inhibited insulin release from rat pancreatic islets, indicating a po...

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Bibliographic Details
Main Authors: Michael Schnekenburger, Eric Goffin, Matthieu Schoumacher, Nikolay Tumanov, Ange Mouithys-Mickalad, Pascal de Tullio, Johan Wouters, Philippe Lebrun, Marc Diederich, Bernard Pirotte
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:European Journal of Medicinal Chemistry Reports
Subjects:
2,2-Dimethylchromans
Racemate
Enantiomeric separation
Pancreatic B-Cell
Potassium channel opener
Anticancer agent
Online Access:http://www.sciencedirect.com/science/article/pii/S277241742400116X

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http://www.sciencedirect.com/science/article/pii/S277241742400116X

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