Gene therapy model of X-linked severe combined immunodeficiency using a modified foamy virus vector.

Gene therapy model of X-linked severe combined immunodeficiency using a modified foamy virus vector.

X-linked severe combined immunodeficiency (SCID-X1) is an inherited genetic immunodeficiency associated with mutations in the common cytokine receptor γ chain (γc) gene, and characterized by a complete defect of T and natural killer (NK) cells. Gene therapy for SCID-X1 using conventional retroviral...

Full description

Bibliographic Details
Main Authors: Satoshi Horino, Toru Uchiyama, Takanori So, Hiroyuki Nagashima, Shu-Lan Sun, Miki Sato, Atsuko Asao, Yoichi Haji, Yoji Sasahara, Fabio Candotti, Shigeru Tsuchiya, Shigeo Kure, Kazuo Sugamura, Naoto Ishii
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3749225?pdf=render

Internet

http://europepmc.org/articles/PMC3749225?pdf=render

Similar Items