Engineered a dual-targeting HA-TPP/A nanoparticle for combination therapy against KRAS-TP53 co-mutation in gastrointestinal cancers

Engineered a dual-targeting HA-TPP/A nanoparticle for combination therapy against KRAS-TP53 co-mutation in gastrointestinal cancers

KRAS-TP53 co-mutation is strongly associated with poor prognosis and high malignancy in gastrointestinal cancers. Therefore, a novel approach to oncotherapy may lie in combination therapy targeting both KRAS and TP53. Herein, we present a novel self-assembled nanoparticle (HA-TPP/A) that are functio...

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Bibliographic Details
Main Authors: Yong Mei, Xiaohua Qin, Zhenyu Yang, Shiyao Song, Xiaoting Liu, Chong Wu, Jieying Qian, Xiaowan Huang, Yunjiao Zhang, Weiling He
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2024-02-01
Series:Bioactive Materials
Subjects:
Dual-targeting
KRAS
TP53
Co-mutation
HA-TPP/A nanoparticle
Mitochondrial targeting
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X23003080

Internet

http://www.sciencedirect.com/science/article/pii/S2452199X23003080

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