Synthesis and antitumor properties of some new N-(5-R-benzyl-1,3-thiazol-2-yl)-4,5-dihydro-1H-imidazole-2-carboxamides
New N-(5-R-benzyl-1,3-thiazol-2-yl)-2-morpholin-4-yl-2-oxoacetamides have been prepared in good yields via the reaction of N-(5-R-benzyl-1,3-thiazol-2-yl)-2-chloroacetamides with sulfur and morfoline. These compounds react with ethendiamine to form a series of novel N-[5-R-benzyl)-1,3-thiazol-2-yl]-...
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| Format: | Article |
| Language: | English |
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Universitas Gadjah Mada
2020-08-01
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| Series: | Indonesian Journal of Pharmacy |
| Subjects: | |
| Online Access: | https://jurnal.ugm.ac.id/v3/IJP/article/view/596 |
| _version_ | 1818932391619592192 |
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| author | Volodymyr Ya Horishny Iryna V Drapak Taras I Chaban Yuriy V Ostapiuk Vasyl S Matiychuk |
| author_facet | Volodymyr Ya Horishny Iryna V Drapak Taras I Chaban Yuriy V Ostapiuk Vasyl S Matiychuk |
| author_sort | Volodymyr Ya Horishny |
| collection | DOAJ |
| description | New N-(5-R-benzyl-1,3-thiazol-2-yl)-2-morpholin-4-yl-2-oxoacetamides have been prepared in good yields via the reaction of N-(5-R-benzyl-1,3-thiazol-2-yl)-2-chloroacetamides with sulfur and morfoline. These compounds react with ethendiamine to form a series of novel N-[5-R-benzyl)-1,3-thiazol-2-yl]-4,5-dihydro-1H-imidazole-2-carboxamides with excellent yields. Anticancer activity screening of synthesized compounds was carried out within the framework of the Developmental Therapeutic Program of the National Cancer Institute's (DTP, NCI, Bethesda, Maryland, USA). It was shown that compounds are promising for new anticancer agents' search. |
| first_indexed | 2024-12-20T04:31:45Z |
| format | Article |
| id | doaj.art-cc774255fd6f40ce8aa038b406206d9d |
| institution | Directory Open Access Journal |
| issn | 2338-9427 2338-9486 |
| language | English |
| last_indexed | 2024-12-20T04:31:45Z |
| publishDate | 2020-08-01 |
| publisher | Universitas Gadjah Mada |
| record_format | Article |
| series | Indonesian Journal of Pharmacy |
| spelling | doaj.art-cc774255fd6f40ce8aa038b406206d9d2022-12-21T19:53:22ZengUniversitas Gadjah MadaIndonesian Journal of Pharmacy2338-94272338-94862020-08-0115016010.22146/ijp.596596Synthesis and antitumor properties of some new N-(5-R-benzyl-1,3-thiazol-2-yl)-4,5-dihydro-1H-imidazole-2-carboxamidesVolodymyr Ya Horishny0Iryna V Drapak1Taras I Chaban2Yuriy V Ostapiuk3Vasyl S Matiychuk4Department of Pharmaceutical, Organic and Bioorganic Chemistry Danylo Halytsky Lviv National Medical University, Lviv, 79010, UkraineDepartment of General, Bioinorganic, Physical and Colloidal Chemistry, Danylo Halytsky Lviv National Medical University, 69 Pekarska, Lviv, 79010, UkraineDepartment of General, Bioinorganic, Physical and Colloidal Chemistry, Danylo Halytsky Lviv National Medical University, 69 Pekarska, Lviv, 79010, UkraineDepartment of Organic Chemistry, Ivan Franko National University of Lviv, 6 Kyryla і Mefodia, Lviv, 79005, UkraineDepartment of Organic Chemistry, Ivan Franko National University of Lviv, 6 Kyryla і Mefodia, Lviv, 79005, UkraineNew N-(5-R-benzyl-1,3-thiazol-2-yl)-2-morpholin-4-yl-2-oxoacetamides have been prepared in good yields via the reaction of N-(5-R-benzyl-1,3-thiazol-2-yl)-2-chloroacetamides with sulfur and morfoline. These compounds react with ethendiamine to form a series of novel N-[5-R-benzyl)-1,3-thiazol-2-yl]-4,5-dihydro-1H-imidazole-2-carboxamides with excellent yields. Anticancer activity screening of synthesized compounds was carried out within the framework of the Developmental Therapeutic Program of the National Cancer Institute's (DTP, NCI, Bethesda, Maryland, USA). It was shown that compounds are promising for new anticancer agents' search.https://jurnal.ugm.ac.id/v3/IJP/article/view/596organic synthesisthiazoleimidazoleanticancer activity |
| spellingShingle | Volodymyr Ya Horishny Iryna V Drapak Taras I Chaban Yuriy V Ostapiuk Vasyl S Matiychuk Synthesis and antitumor properties of some new N-(5-R-benzyl-1,3-thiazol-2-yl)-4,5-dihydro-1H-imidazole-2-carboxamides Indonesian Journal of Pharmacy organic synthesis thiazole imidazole anticancer activity |
| title | Synthesis and antitumor properties of some new N-(5-R-benzyl-1,3-thiazol-2-yl)-4,5-dihydro-1H-imidazole-2-carboxamides |
| title_full | Synthesis and antitumor properties of some new N-(5-R-benzyl-1,3-thiazol-2-yl)-4,5-dihydro-1H-imidazole-2-carboxamides |
| title_fullStr | Synthesis and antitumor properties of some new N-(5-R-benzyl-1,3-thiazol-2-yl)-4,5-dihydro-1H-imidazole-2-carboxamides |
| title_full_unstemmed | Synthesis and antitumor properties of some new N-(5-R-benzyl-1,3-thiazol-2-yl)-4,5-dihydro-1H-imidazole-2-carboxamides |
| title_short | Synthesis and antitumor properties of some new N-(5-R-benzyl-1,3-thiazol-2-yl)-4,5-dihydro-1H-imidazole-2-carboxamides |
| title_sort | synthesis and antitumor properties of some new n 5 r benzyl 1 3 thiazol 2 yl 4 5 dihydro 1h imidazole 2 carboxamides |
| topic | organic synthesis thiazole imidazole anticancer activity |
| url | https://jurnal.ugm.ac.id/v3/IJP/article/view/596 |
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