Suboptimal Concentrations of Ceftazidime/Avibactam (CAZ-AVI) May Select for CAZ-AVI Resistance in Extensively Drug-Resistant <i>Pseudomonas aeruginosa</i>: In Vivo and In Vitro Evidence

Suboptimal Concentrations of Ceftazidime/Avibactam (CAZ-AVI) May Select for CAZ-AVI Resistance in Extensively Drug-Resistant <i>Pseudomonas aeruginosa</i>: In Vivo and In Vitro Evidence

This study correlates in vivo findings in a patient with an extensively drug-resistant (XDR) <i>P. aeruginosa</i> infection who developed resistance to ceftazidime-avibactam (CAZ-AVI) with in vitro results of a 7-day hollow-fiber infection model (HFIM) testing the same bacterial strain....

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Bibliographic Details
Main Authors: Inmaculada Lopez-Montesinos, María Milagro Montero, Sandra Domene-Ochoa, Carla López-Causapé, Daniel Echeverria, Luisa Sorlí, Nuria Campillo, Sonia Luque, Eduardo Padilla, Nuria Prim, Santiago Grau, Antonio Oliver, Juan P. Horcajada
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Antibiotics
Subjects:
ceftazidime/avibactam
<i>Pseudomonas aeruginosa</i>
multidrug-resistant
continuous infusion
PK/PD
hollow fiber
Online Access:https://www.mdpi.com/2079-6382/11/11/1456

Internet

https://www.mdpi.com/2079-6382/11/11/1456

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