Distinctive cell‐free DNA methylation characterizes presymptomatic genetic frontotemporal dementia

Distinctive cell‐free DNA methylation characterizes presymptomatic genetic frontotemporal dementia

Abstract Objective Methylation of plasma cell‐free DNA (cfDNA) has potential as a marker of brain damage in neurodegenerative diseases such as frontotemporal dementia (FTD). Here, we study methylation of cfDNA in presymptomatic and symptomatic carriers of genetic FTD pathogenic variants, next to hea...

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Bibliographic Details
Main Authors: Lucia A. A. Giannini, Ruben G. Boers, Emma L. van derEnde, Jackie M. Poos, Lize C. Jiskoot, Joachim B. Boers, Wilfred F. J. vanIJcken, Elise G. Dopper, Yolande A. L. Pijnenburg, Harro Seelaar, Lieke H. Meeter, Jeroen G. J. vanRooij, Wiep Scheper, Joost Gribnau, John C. vanSwieten
Format: Article
Language:English
Published: Wiley 2024-03-01
Series:Annals of Clinical and Translational Neurology
Online Access:https://doi.org/10.1002/acn3.51997

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https://doi.org/10.1002/acn3.51997

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