An extensive β1-adrenergic receptor gene signaling network regulates molecular remodeling in dilated cardiomyopathies

An extensive β1-adrenergic receptor gene signaling network regulates molecular remodeling in dilated cardiomyopathies

We investigated the extent, biologic characterization, phenotypic specificity, and possible regulation of a β1-adrenergic receptor–linked (β1-AR–linked) gene signaling network (β1-GSN) involved in left ventricular (LV) eccentric pathologic remodeling. A 430-member β1-GSN was identified by mRNA expre...

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Bibliographic Details
Main Authors: Philip D. Tatman, David P. Kao, Kathryn C. Chatfield, Ian A. Carroll, Jessica A. Wagner, Eric R. Jonas, Carmen C. Sucharov, J. David Port, Brian D. Lowes, Wayne A. Minobe, Sophia P. Huebler, Anis Karimpour-Fard, Erin M. Rodriguez, Stephen B. Liggett, Michael R. Bristow
Format: Article
Language:English
Published: American Society for Clinical investigation 2023-08-01
Series:JCI Insight
Subjects:
Cardiology
Genetics
Online Access:https://doi.org/10.1172/jci.insight.169720

Internet

https://doi.org/10.1172/jci.insight.169720

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