Poxvirus-Based Active Immunotherapy with PD-1 and LAG-3 Dual Immune Checkpoint Inhibition Overcomes Compensatory Immune Regulation, Yielding Complete Tumor Regression in Mice.

Poxvirus-Based Active Immunotherapy with PD-1 and LAG-3 Dual Immune Checkpoint Inhibition Overcomes Compensatory Immune Regulation, Yielding Complete Tumor Regression in Mice.

Poxvirus-based active immunotherapies mediate anti-tumor efficacy by triggering broad and durable Th1 dominated T cell responses against the tumor. While monotherapy significantly delays tumor growth, it often does not lead to complete tumor regression. It was hypothesized that the induced robust in...

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Bibliographic Details
Main Authors: Susan P Foy, Barbara Sennino, Tracy dela Cruz, Joseph J Cote, Evan J Gordon, Felicia Kemp, Veronica Xavier, Alex Franzusoff, Ryan B Rountree, Stefanie J Mandl
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4765931?pdf=render

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http://europepmc.org/articles/PMC4765931?pdf=render

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