Structural communication between the GTPase Sec4p and its activator Sec2p: Determinants of GEF activity and early deformations to nucleotide release

Structural communication between the GTPase Sec4p and its activator Sec2p: Determinants of GEF activity and early deformations to nucleotide release

Ras GTPases are molecular switches that cycle between OFF and ON states depending on the bound nucleotide (i.e. GDP-bound and GTP-bound, respectively).The Rab GTPase, Sec4p, plays regulatory roles in multiple steps of intracellular vesicle trafficking. Nucleotide release is catalyzed by the Guanine...

Full description

Bibliographic Details
Main Authors: Angelo Felline, Francesco Raimondi, Sara Gentile, Francesca Fanelli
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Molecular dynamics simulations
Protein–protein docking
Ras GTPases
Guanine nucleotide exchange factor
Protein structure network
Structural communication
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037022004214

Internet

http://www.sciencedirect.com/science/article/pii/S2001037022004214

Similar Items