High-resolution subtyping of fibroblasts in gastric cancer reveals diversity among fibroblast subsets and an association between the MFAP5-fibroblast subset and immunotherapy

High-resolution subtyping of fibroblasts in gastric cancer reveals diversity among fibroblast subsets and an association between the MFAP5-fibroblast subset and immunotherapy

BackgroundsGastric cancer (GC) remains a global health threat due to frequent treatment failures caused by primary or acquired resistance. Although cancer-associated fibroblasts (CAFs) have been implicated in this process, it is still unclear which specific subtype(s) of CAFs hinder T-cell infiltrat...

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Bibliographic Details
Main Authors: Hong Wang, Linjun Yang, Wei Chen, Kainan Li, Meng Xu, Xiaobo Peng, Jie Li, Feng Zhao, Bin Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-10-01
Series:Frontiers in Immunology
Subjects:
gastric cancer
fibroblast
single cell RNA sequencing
MFAP5
immunotherapy
precision medicine
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1446613/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1446613/full

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