Memantine attenuates the development of osteoarthritis by blocking NMDA receptor mediated calcium overload and chondrocyte senescence

Memantine attenuates the development of osteoarthritis by blocking NMDA receptor mediated calcium overload and chondrocyte senescence

Background: Memantine, which is an FDA-proven drug for the treatment of dementia, exerts its function by blocking the function of NMDA (N-methyl-D-aspartate) receptor, a calcium-permeable ion channel that reduces cytotoxic calcium overload. Chondrocyte senescence is a crucial cellular event that con...

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Bibliographic Details
Main Authors: Qingmei Cheng, Ke He, Junyu Zhu, Xiaoxiao Li, Xuan Wu, Chao Zeng, Guanghua Lei, Ning Wang, Hui Li, Jie Wei
Format: Article
Language:English
Published: Elsevier 2024-09-01
Series:Journal of Orthopaedic Translation
Subjects:
Chondrocyte senescence
Memantine
Mitochondria
NMDA receptor
Osteoarthritis
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X24000949

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http://www.sciencedirect.com/science/article/pii/S2214031X24000949

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