A cell-based infection assay identifies efflux pump modulators that reduce bacterial intracellular load.

A cell-based infection assay identifies efflux pump modulators that reduce bacterial intracellular load.

Bacterial efflux pumps transport small molecules from the cytoplasm or periplasm outside the cell. Efflux pump activity is typically increased in multi-drug resistant (MDR) pathogens; chemicals that inhibit efflux pumps may have potential for antibiotic development. Using an in-cell screen, we ident...

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Bibliographic Details
Main Authors: Abigail L Reens, Amy L Crooks, Chih-Chia Su, Toni A Nagy, David L Reens, Jessica D Podoll, Madeline E Edwards, Edward W Yu, Corrella S Detweiler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-06-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1007115

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https://doi.org/10.1371/journal.ppat.1007115

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