Effect of a selective nonsteroidal anti-inflammatory inhibitor of cyclooxygenase-2 on the small bowel of rats

Effect of a selective nonsteroidal anti-inflammatory inhibitor of cyclooxygenase-2 on the small bowel of rats

The pathogenesis of nonsteroidal anti-inflammatory drug (NSAID) enteropathy is a complex process involving the uncoupling of mitochondrial oxidative phosphorylation and inhibition of cyclooxygenase (COX). Rofecoxib, a selective inhibitor of COX-2, has shown less gastric damage, but the same benefici...

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Bibliographic Details
Main Authors: A.Z.A. Leite, A.M. Sipahi, A.O.M.C. Damião, A.T. Garcez, C.A. Buchpiguel, F.P. Lopasso, M.L.L. Lordello, C.L.O. Agostinho, A.A. Laudanna
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2004-03-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Intestinal permeability
Enteropathy
Nonsteroidal anti-inflammatory drugs
Indomethacin
Rofecoxib
COX-2 inhibitor
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000300007

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000300007

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