A systems biology approach identifies the role of dysregulated PRDM6 in the development of hypertension

A systems biology approach identifies the role of dysregulated PRDM6 in the development of hypertension

Genetic variants in the third intron of the PRDM6 gene have been associated with BP traits in multiple GWAS. By combining fine mapping, massively parallel reporter assays, and gene editing, we identified super enhancers that drive the expression of PRDM6 and are partly regulated by STAT1 as the caus...

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Bibliographic Details
Main Authors: Kushan L. Gunawardhana, Lingjuan Hong, Trojan Rugira, Severin Uebbing, Joanna Kucharczak, Sameet Mehta, Dineth R. Karunamuni, Brenda Cabera-Mendoza, Neeru Gandotra, Curt Scharfe, Renato Polimanti, James P. Noonan, Arya Mani
Format: Article
Language:English
Published: American Society for Clinical Investigation 2023-03-01
Series:The Journal of Clinical Investigation
Subjects:
Cardiology
Nephrology
Online Access:https://doi.org/10.1172/JCI160036

Internet

https://doi.org/10.1172/JCI160036

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