ATP128 Clinical Therapeutic Cancer Vaccine Activates NF-κB and IRF3 Pathways through TLR4 and TLR2 in Human Monocytes and Dendritic Cells

ATP128 Clinical Therapeutic Cancer Vaccine Activates NF-κB and IRF3 Pathways through TLR4 and TLR2 in Human Monocytes and Dendritic Cells

The use of cancer vaccines is a promising therapeutic strategy able to stimulate anti-tumor immunity by inducing both humoral and cellular immunity. In this study, antigen presenting cells play a key role by inducing a strong activation of the T cell-mediated adaptive immune response, essential for...

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Bibliographic Details
Main Authors: Roberta Pascolutti, Lakshmi Yeturu, Géraldine Philippin, Stéphane Costa Borges, Magali Dejob, Marie-Laure Santiago-Raber, Madiha Derouazi
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cancers
Subjects:
therapeutic cancer vaccine
self-adjuvanticity
toll-like receptor 2
toll-like receptor 4
dendritic cells activation
Online Access:https://www.mdpi.com/2072-6694/14/20/5134

Internet

https://www.mdpi.com/2072-6694/14/20/5134

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