Synthesis and anticancer activity of podophyllotoxin derivatives with nitrogen-containing heterocycles

Synthesis and anticancer activity of podophyllotoxin derivatives with nitrogen-containing heterocycles

Three series of podophyllotoxin derivatives with various nitrogen-containing heterocycles were designed and synthesized. The antitumor activity of these podophyllotoxin derivatives was evaluated in vitro against a panel of human tumor cell lines. The results showed that podophyllotoxin-imidazolium s...

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Bibliographic Details
Main Authors: Meng Yin, Yongsheng Fang, Xiaotong Sun, Minggao Xue, Caimei Zhang, Zhiyun Zhu, Yamiao Meng, Lingmei Kong, Yi Yi Myint, Yan Li, Jingfeng Zhao, Xiaodong Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Chemistry
Subjects:
podophyllotoxin
imidazolium salts
triazoles
antitumor activity
structure-activity relationships
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2023.1191498/full

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https://www.frontiersin.org/articles/10.3389/fchem.2023.1191498/full

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