Engineering brain activity patterns by neuromodulator polytherapy for treatment of disorders

Brain disorders are associated with network dysfunctions that are not addressed by conventional drug screens. Here, the authors use high-throughput functional imaging of brain activity in zebrafish larvae to study the effects of individual drugs on network connectivity and demonstrate an algorithm t...

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Bibliographic Details
Main Authors: Mostafa Ghannad-Rezaie, Peter M. Eimon, Yuelong Wu, Mehmet Fatih Yanik
Format: Article
Language:English
Published: Nature Portfolio 2019-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10541-1