Using single-cell multiple omics approaches to resolve tumor heterogeneity

Using single-cell multiple omics approaches to resolve tumor heterogeneity

Abstract It has become increasingly clear that both normal and cancer tissues are composed of heterogeneous populations. Genetic variation can be attributed to the downstream effects of inherited mutations, environmental factors, or inaccurately resolved errors in transcription and replication. When...

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Bibliographic Details
Main Authors: Michael A. Ortega, Olivier Poirion, Xun Zhu, Sijia Huang, Thomas K. Wolfgruber, Robert Sebra, Lana X. Garmire
Format: Article
Language:English
Published: Wiley 2017-12-01
Series:Clinical and Translational Medicine
Subjects:
Single-cell sequencing
Cancer
Mutation
Gene expression
Methylation
Heterogeneity
Online Access:http://link.springer.com/article/10.1186/s40169-017-0177-y

Internet

http://link.springer.com/article/10.1186/s40169-017-0177-y

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