Novelty Search Promotes Antigenic Diversity in Microbial Pathogens

Novelty Search Promotes Antigenic Diversity in Microbial Pathogens

Driven by host–pathogen coevolution, cell surface antigens are often the fastest evolving parts of a microbial pathogen. The persistent evolutionary impetus for novel antigen variants suggests the utility of novelty-seeking algorithms in predicting antigen diversification in microbial pathogens. In...

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Bibliographic Details
Main Authors: Brandon Ely, Winston Koh, Eamen Ho, Tasmina M. Hassan, Anh V. Pham, Weigang Qiu
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Pathogens
Subjects:
surface antigen
antigenic variation
fitness landscape
evolution
genetic algorithm
novelty search
Online Access:https://www.mdpi.com/2076-0817/12/3/388

Internet

https://www.mdpi.com/2076-0817/12/3/388

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