PM2.5 promotes NSCLC carcinogenesis through translationally and transcriptionally activating DLAT-mediated glycolysis reprograming

PM2.5 promotes NSCLC carcinogenesis through translationally and transcriptionally activating DLAT-mediated glycolysis reprograming

Abstract Background Airborne fine particulate matter (PM2.5) has been associated with lung cancer development and progression in never smokers. However, the molecular mechanisms underlying PM2.5-induced lung cancer remain largely unknown. The aim of this study was to explore the mechanisms by which...

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Bibliographic Details
Main Authors: Qianqian Chen, Yiling Wang, Lin Yang, Liyuan Sun, Yuxin Wen, Yongyi Huang, Kaiping Gao, Wenhan Yang, Feng Bai, Lijuan Ling, Zizi Zhou, Xiaoming Zhang, Juan Xiong, Rihong Zhai
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
PM2.5
Glycolysis reprograming
Non-small cell lung cancer (NSCLC)
DLAT
eIF4E
Sp1
Online Access:https://doi.org/10.1186/s13046-022-02437-8

Internet

https://doi.org/10.1186/s13046-022-02437-8

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