A new model to study spinal muscular atrophy: Neurite degeneration and cell death is counteracted by BCL-XL Overexpression in motoneurons

A new model to study spinal muscular atrophy: Neurite degeneration and cell death is counteracted by BCL-XL Overexpression in motoneurons

Spinal muscular atrophy (SMA) is a motoneuron disorder characterized by deletions or specific mutations in the Survival Motor Neuron gene (SMN). SMN is ubiquitously expressed and has a general role in the assembly of small nuclear ribonucleoprotein (snRNP) and pre-mRNA splicing requirements. However...

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Bibliographic Details
Main Authors: Ana Garcera, Stefka Mincheva, Myriam Gou-Fabregas, Víctor Caraballo-Miralles, Jerònia Lladó, Joan X. Comella, Rosa M. Soler
Format: Article
Language:English
Published: Elsevier 2011-06-01
Series:Neurobiology of Disease
Subjects:
Spinal Muscular Atrophy
Motoneuron
Neurotrophic factors
Bcl-xL
Survival Motor Neuron
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611100057X

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http://www.sciencedirect.com/science/article/pii/S096999611100057X

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