Mechanical activation of TWIK-related potassium channel by nanoscopic movement and rapid second messenger signaling

Mechanical activation of TWIK-related potassium channel by nanoscopic movement and rapid second messenger signaling

Rapid conversion of force into a biological signal enables living cells to respond to mechanical forces in their environment. The force is believed to initially affect the plasma membrane and then alter the behavior of membrane proteins. Phospholipase D2 (PLD2) is a mechanosensitive enzyme that is r...

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Bibliographic Details
Main Authors: E Nicholas Petersen, Mahmud Arif Pavel, Samuel S Hansen, Manasa Gudheti, Hao Wang, Zixuan Yuan, Keith R Murphy, William Ja, Heather A Ferris, Erik Jorgensen, Scott B Hansen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-02-01
Series:eLife
Subjects:
cholesterol
mechanosensation
PIP2
TREK
shear thinning
lipid raft
Online Access:https://elifesciences.org/articles/89465

Internet

https://elifesciences.org/articles/89465

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