BRCA1-A and BRISC: Multifunctional Molecular Machines for Ubiquitin Signaling
The K63-linkage specific deubiquitinase BRCC36 forms the core of two multi-subunit deubiquitination complexes: BRCA1-A and BRISC. BRCA1-A is recruited to DNA repair <i>foci</i>, edits ubiquitin signals on chromatin, and sequesters BRCA1 away from the site of damage, suppressing homologou...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/10/11/1503 |