3,3′-Diindolylmethane Enhances Fluorouracil Sensitivity via Inhibition of Pyrimidine Metabolism in Colorectal Cancer

3,3′-Diindolylmethane Enhances Fluorouracil Sensitivity via Inhibition of Pyrimidine Metabolism in Colorectal Cancer

Chemoresistance limits treatment outcomes in colorectal cancer (CRC) patients. A dimeric metabolite of indole-3-carbinol, 3,3′-diindolylmethane (DIM) is abundant in cruciferous vegetables and has shown anticancer efficacy. The role of DIM in regulating chemosensitivity in CRC remains unknown. In thi...

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Bibliographic Details
Main Authors: Jieping Zhang, Shaomin Zou, Yijing Zhang, Ziqing Yang, Wencong Wang, Manqi Meng, Junyan Feng, Peng Zhang, Lishi Xiao, Mong-Hong Lee, Lekun Fang
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Metabolites
Subjects:
colorectal cancer
3,3′-Diindolylmethane
chemosensitivity
pyrimidine metabolism
Online Access:https://www.mdpi.com/2218-1989/12/5/410

Internet

https://www.mdpi.com/2218-1989/12/5/410

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