SRPS associated protein WDR60 regulates the multipolar-to-bipolar transition of migrating neurons during cortical development

Abstract Mutations of WD40 repeat domain 60 (WDR60) have been identified in short-rib polydactyly syndromes (SRPS I–V), a group of lethal congenital disorders characterized by short ribs, polydactyly, and a range of extraskeletal phenotypes. However, the underlying mechanism is still unclear. Here,...

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Bibliographic Details
Main Authors: Cui Li, Yu Zheng, Yufang Zheng, Zhiheng Xu
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-020-03363-3