Ni-catalyzed hydroarylation of alkynes with unactivated β-C(sp2)−H bonds
Directed activation of C–H bonds usually occurs through 5-membered metallacycles, which poses limitations of regiochemistry. Herein, the authors use a phosphine oxide-ligated Ni−Al bimetallic catalyst to enable β-C−H bond-involved hydroarylations of alkynes via a rare 7-membered nickelacycle.
| Hoofdauteurs: | , , , , |
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| Formaat: | Artikel |
| Taal: | English |
| Gepubliceerd in: |
Nature Portfolio
2022-05-01
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| Reeks: | Nature Communications |
| Online toegang: | https://doi.org/10.1038/s41467-022-30367-8 |
| Samenvatting: | Directed activation of C–H bonds usually occurs through 5-membered metallacycles, which poses limitations of regiochemistry. Herein, the authors use a phosphine oxide-ligated Ni−Al bimetallic catalyst to enable β-C−H bond-involved hydroarylations of alkynes via a rare 7-membered nickelacycle. |
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| ISSN: | 2041-1723 |