Forskolin sensitizes pancreatic cancer cells to gemcitabine via Stat3 and Erk1/2 inhibition

Forskolin sensitizes pancreatic cancer cells to gemcitabine via Stat3 and Erk1/2 inhibition

Cytotoxic chemotherapy, including gemcitabine-based regimens, represents the mainstay of treatment for locally advanced and metastatic pancreatic cancer. However, the response to chemotherapy is absolutely unsatisfactory and the prognosis of pancreatic cancer remains very poor. Therefore, it would b...

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Bibliographic Details
Main Authors: Michela Illiano, Luigi Sapio, Ilaria Caiafa, Emilio Chiosi, Annamaria Spina, Silvio Naviglio
Format: Article
Language:English
Published: AIMS Press 2017-06-01
Series:AIMS Molecular Science
Subjects:
forskolin
gemcitabine
Erk1/2
Stat3
pancreatic cancer
combination therapy
Online Access:http://www.aimspress.com/Molecular/article/1476/fulltext.html

Internet

http://www.aimspress.com/Molecular/article/1476/fulltext.html

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