Broadly neutralizing human antibodies against dengue virus identified by single B cell transcriptomics

Broadly neutralizing human antibodies against dengue virus identified by single B cell transcriptomics

Eliciting broadly neutralizing antibodies (bNAbs) against the four dengue virus serotypes (DENV1-4) that are spreading into new territories is an important goal of vaccine design. To define bNAb targets, we characterized 28 antibodies belonging to expanded and hypermutated clonal families identified...

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Bibliographic Details
Main Authors: Natasha D Durham, Aditi Agrawal, Eric Waltari, Derek Croote, Fabio Zanini, Mallorie Fouch, Edgar Davidson, Olivia Smith, Esteban Carabajal, John E Pak, Benjamin J Doranz, Makeda Robinson, Ana M Sanz, Ludwig L Albornoz, Fernando Rosso, Shirit Einav, Stephen R Quake, Krista M McCutcheon, Leslie Goo
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-12-01
Series:eLife
Subjects:
flavivirus
neutralizing antibodies
dengue virus
B cell repertoire
single cell transcriptomics
Online Access:https://elifesciences.org/articles/52384

Internet

https://elifesciences.org/articles/52384

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