NTRK1/TrkA Signaling in Neuroblastoma Cells Induces Nuclear Reorganization and Intra-Nuclear Aggregation of Lamin A/C

NTRK1/TrkA Signaling in Neuroblastoma Cells Induces Nuclear Reorganization and Intra-Nuclear Aggregation of Lamin A/C

(1) Background: Neuroblastomas (NBs) are the most common extracranial solid tumors of children. The amplification of the Myc-N proto-oncogene (MYCN) is a major driver of NB aggressiveness, while high expression of the neurotrophin receptor NTRK1/TrkA is associated with mild disease courses. The mole...

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Bibliographic Details
Main Authors: Lukas Funke, Thilo Bracht, Sebastian Oeck, Karin Schork, Markus Stepath, Sabine Dreesmann, Martin Eisenacher, Barbara Sitek, Alexander Schramm
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cancers
Subjects:
phosphoproteomics
mass spectrometry
phosphorylation
proteomics
MYCN
nuclear foci
Online Access:https://www.mdpi.com/2072-6694/13/21/5293

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https://www.mdpi.com/2072-6694/13/21/5293

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