Simultaneous targeting of Tim3 and A2a receptors modulates MSLN-CAR T cell antitumor function in a human cervical tumor xenograft model

Simultaneous targeting of Tim3 and A2a receptors modulates MSLN-CAR T cell antitumor function in a human cervical tumor xenograft model

IntroductionChimeric antigen receptor (CAR) T cell therapy has transformed the treatment of hematological malignancies. However, its efficacy in solid tumors is limited by the immunosuppressive tumor microenvironment that compromises CAR T cell antitumor function in clinical settings. To overcome th...

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Bibliographic Details
Main Authors: Tahereh Soltantoyeh, Behnia Akbari, Zahra Shahosseini, Hamid Reza Mirzaei, Jamshid Hadjati
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-05-01
Series:Frontiers in Immunology
Subjects:
CAR T cell therapy
solid tumors
genetic targeting
xenograft
A2aR
Tim3
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1362904/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1362904/full

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