A New Inhibitor of Tubulin Polymerization Kills Multiple Cancer Cell Types and Reveals p21-Mediated Mechanism Determining Cell Death after Mitotic Catastrophe

A New Inhibitor of Tubulin Polymerization Kills Multiple Cancer Cell Types and Reveals p21-Mediated Mechanism Determining Cell Death after Mitotic Catastrophe

Induction of mitotic catastrophe through the disruption of microtubules is an established target in cancer therapy. However, the molecular mechanisms determining the mitotic catastrophe and the following apoptotic or non-apoptotic cell death remain poorly understood. Moreover, many existing drugs ta...

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Bibliographic Details
Main Authors: Mykola Zdioruk, Andrew Want, Anna Mietelska-Porowska, Katarzyna Laskowska-Kaszub, Joanna Wojsiat, Agata Klejman, Ewelina Użarowska, Paulina Koza, Sylwia Olejniczak, Stanislaw Pikul, Witold Konopka, Jakub Golab, Urszula Wojda
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cancers
Subjects:
cancer
chemotherapeutic
microtubule-poison
vincristine
mitotic catastrophe
non-apoptotic cell death
Online Access:https://www.mdpi.com/2072-6694/12/8/2161

Internet

https://www.mdpi.com/2072-6694/12/8/2161

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