The Two-Component System CopRS Maintains Subfemtomolar Levels of Free Copper in the Periplasm of <named-content content-type="genus-species">Pseudomonas aeruginosa</named-content> Using a Phosphatase-Based Mechanism

The Two-Component System CopRS Maintains Subfemtomolar Levels of Free Copper in the Periplasm of <named-content content-type="genus-species">Pseudomonas aeruginosa</named-content> Using a Phosphatase-Based Mechanism

ABSTRACT Two-component systems control periplasmic Cu+ homeostasis in Gram-negative bacteria. In characterized systems such as Escherichia coli CusRS, upon Cu+ binding to the periplasmic sensing region of CusS, a cytoplasmic phosphotransfer domain of the sensor phosphorylates the response regulator...

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Bibliographic Details
Main Authors: Lorena Novoa-Aponte, Cheng Xu, Fernando C. Soncini, José M. Argüello
Format: Article
Language:English
Published: American Society for Microbiology 2020-12-01
Series:mSphere
Subjects:
Pseudomonas aeruginosa
copper
homeostasis
periplasm
two-component regulatory systems
Online Access:https://journals.asm.org/doi/10.1128/mSphere.01193-20

Internet

https://journals.asm.org/doi/10.1128/mSphere.01193-20

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