Synthesis, Crystal Structure, and Biological Activity of Ethyl 4-Methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylate Polymorphic Forms

Synthesis, Crystal Structure, and Biological Activity of Ethyl 4-Methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylate Polymorphic Forms

Continuing the search for new potential analgesics among the derivatives of 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic acid, the possibility of obtaining its esters by the alkylation of the corresponding sodium salt with iodoethane in dimethyl sulfoxide (DMSO) at room temperat...

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Bibliographic Details
Main Authors: Igor V. Ukrainets, Anna A. Burian, Vyacheslav N. Baumer, Svitlana V. Shishkina, Lyudmila V. Sidorenko, Igor A. Tugaibei, Natali I. Voloshchuk, Pavlo S. Bondarenko
Format: Article
Language:English
Published: MDPI AG 2018-05-01
Series:Scientia Pharmaceutica
Subjects:
alkylation
esters
4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic acid
2,1-benzothiazine
crystal structure
polymorphism
anti-inflammatory action
analgesic activity
Online Access:http://www.mdpi.com/2218-0532/86/2/21

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http://www.mdpi.com/2218-0532/86/2/21

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