Hypoxia pathways and cellular stress activate pancreatic stellate cells: development of an organotypic culture model of thick slices of normal human pancreas.

Hypoxia pathways and cellular stress activate pancreatic stellate cells: development of an organotypic culture model of thick slices of normal human pancreas.

Pancreatic stellate cells (PSC) are involved in fibrogenesis and oncogenesis by modulating the extracellular matrix.To evaluate the effect of cellular stress on PSC activation using a model of normal human pancreatic tissue slices culture preserving the microenvironment.Thin sections (300 μm) of nor...

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Bibliographic Details
Main Authors: Vinciane Rebours, Miguel Albuquerque, Alain Sauvanet, Philippe Ruszniewski, Philippe Lévy, Valérie Paradis, Pierre Bedossa, Anne Couvelard
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3786955?pdf=render

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http://europepmc.org/articles/PMC3786955?pdf=render

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